What Are the Challenges in Drug Target Identification Using Histology?
Despite its advantages, there are challenges in using histology for drug target identification:
Tissue Heterogeneity: Different regions of a tissue may exhibit varying expressions of potential targets, complicating the identification process. Antibody Specificity: The reliability of IHC depends on the specificity of antibodies used to detect targets. Non-specific binding can lead to false positives. Quantification Challenges: Quantifying protein or gene expression levels in histological samples can be difficult and may require advanced imaging and analysis techniques.
