What are the Cellular Mechanisms Behind Central Nucleation?
The cellular mechanisms behind central nucleation involve the activation and differentiation of satellite cells. Upon muscle injury, satellite cells become activated, proliferate, and fuse to form new myotubes with centrally located nuclei. Over time, as the myotubes mature, the nuclei migrate to the periphery. This process is regulated by various molecular signals and pathways, including the Notch signaling pathway and growth factors.
