What are Some Examples of Initiator Caspases in Histological Studies?
In cancer histology, studies often focus on caspase-8 and its role in the extrinsic apoptotic pathway initiated by death receptors like Fas and TNF receptors. In neurobiology, caspase-9 is frequently studied for its role in the intrinsic apoptotic pathway mediated by mitochondrial signals. In developmental biology, caspase-2 has been shown to play a role in oogenesis and neuronal development, highlighting its importance in tissue formation and differentiation.
