What Are Some Examples of Drug Resistance Mechanisms Observed in Histology?

- P-glycoprotein Overexpression: This efflux pump protein can be detected via immunohistochemistry and is a common mechanism of multidrug resistance.
- Mutations in Target Proteins: Histological techniques can identify changes in proteins such as EGFR, which may alter drug binding and efficacy.
- Increased DNA Repair: Cells may show upregulation of DNA repair enzymes, detectable through specific staining techniques, allowing them to survive chemotherapeutic damage.