What is the Role of TGF β Receptor Type I in Cell Signaling?
When TGF β binds to the receptor complex, type II receptor phosphorylates and activates TGF β receptor type I. This activated receptor then propagates the signal by phosphorylating receptor-regulated SMAD proteins (R-SMADs), which translocate to the nucleus to regulate gene expression. This signaling pathway is vital for various cellular functions such as proliferation, apoptosis, and differentiation.
