What Are Some Challenges in Studying Death Ligands?
Studying death ligands involves several challenges, including the complexity of their signaling pathways and the context-dependent nature of their effects. For instance, while TNF-α can induce apoptosis, it can also promote cell survival and inflammation through NF-κB signaling. Additionally, the redundancy and overlap between different death ligands and their receptors add another layer of complexity to their study.
