What are Potential Therapeutic Targets Related to Pancreatic Stellate Cells?
Given their pivotal role in fibrosis and cancer, PSCs are considered potential therapeutic targets. Strategies to inhibit PSC activation or promote their reversion to a quiescent state include:
- Antioxidants to reduce oxidative stress. - Inhibitors of cytokines like TGF-β and PDGF. - Gene therapy approaches to modulate the expression of fibrosis-related genes. - Natural compounds such as curcumin, which has been shown to inhibit PSC activation.
