GPI-anchored proteins are a diverse group of proteins that are attached to the cell membrane via a glycosylphosphatidylinositol anchor. These proteins play crucial roles in various cellular functions, including signal transduction, cell adhesion, and enzymatic processes. In PNH, the deficiency of these proteins, particularly CD55 and CD59, on red blood cells leads to uncontrolled activation of the complement system, resulting in hemolysis.
