What Histological Changes Occur with FGFR2 Mutations?

Histological examination of tissues with FGFR2 mutations often reveals abnormalities in cell proliferation and differentiation. For instance, in cancers, overexpression or mutations of FGFR2 can lead to uncontrolled cell growth and tumor formation. In genetic disorders affecting bone development, histological changes may include abnormal bone morphology and premature fusion of cranial sutures. These changes can be identified using techniques such as IHC and histopathological staining.