Currently, there is no cure for Hemoglobin Bart's, especially in its most severe form. Management focuses on supportive care and symptom relief. In cases detected prenatally, options such as intrauterine transfusions may be considered to improve fetal outcomes. Postnatal treatment may involve regular blood transfusions, iron chelation therapy to prevent iron overload, and in some cases, bone marrow transplantation. Advances in gene therapy hold promise for future treatments, but they are still in experimental stages.