Diagnosis of TTR amyloidosis often involves a combination of clinical assessment, imaging studies, and histological examination of tissue biopsies. Congo red staining of tissue sections, followed by examination under polarized light, can reveal apple-green birefringence indicative of amyloid. Immunohistochemistry can further confirm the presence of TTR within the amyloid deposits. Genetic testing may also be performed to identify mutations in the TTR gene that predispose individuals to hereditary forms of the disease.
