Regulation of the interferon response is critical to prevent excessive tissue damage. This regulation occurs at multiple levels, including the control of interferon production, signaling, and the action of ISGs. Negative feedback mechanisms, such as the production of SOCS proteins and the expression of interferon regulatory factors (IRFs), help to attenuate the response. Chronic activation of the interferon response can lead to pathological conditions, such as autoimmune diseases where the body's immune system attacks its own tissues.
