The effect of interferons on tissue histology is multifaceted. In infected tissues, interferons induce an inflammatory response, which can lead to increased infiltration of immune cells such as lymphocytes, macrophages, and dendritic cells. This can be observed histologically as an increase in cellularity and changes in the architecture of the tissue. For instance, in the liver, interferon response to viral hepatitis can result in the appearance of lymphocytic infiltration and hepatocyte apoptosis, leading to inflammation and fibrosis over time.
