In histological studies, RYR1 can be examined using various techniques. Immunohistochemistry is commonly used to visualize the localization and expression of RYR1 in muscle tissues. Antibodies specific to RYR1 are employed to stain tissue sections, allowing researchers to observe the distribution of the receptor. Additionally, electron microscopy can be used to study the ultrastructural features of the sarcoplasmic reticulum and the arrangement of RYR1 channels.