In histology, proteomics can be applied in numerous ways. By combining histological and proteomic techniques, researchers can obtain a detailed map of protein expression and localization within tissues. Applications include identifying biomarkers for diseases, understanding tissue-specific protein functions, and studying the effects of various treatments on tissue proteins. Histological techniques such as immunohistochemistry can be combined with mass spectrometry-based proteomics to identify and quantify proteins in tissue sections.