Proliferative activity can be measured through various techniques in histology. The most common methods include:
1. Ki-67 Staining: This is a nuclear protein associated with cellular proliferation. Ki-67 is present in all active phases of the cell cycle except G0. 2. BrdU (Bromodeoxyuridine) Incorporation: This method involves the incorporation of BrdU into newly synthesized DNA and is detected using specific antibodies. 3. Flow Cytometry: This technique measures the DNA content of cells to determine the proportion of cells in different phases of the cell cycle. 4. Mitotic Index: This is the ratio of cells undergoing mitosis to the total number of cells.
