Dysregulation of PDGFR signaling is implicated in several pathological conditions. Overexpression or mutation of PDGFR can lead to cancer, such as glioblastoma and sarcoma, where the receptor's signaling promotes uncontrolled cell growth. Additionally, PDGFR plays a role in fibrotic diseases by driving the proliferation of fibroblasts and excessive extracellular matrix production.
