Despite its advantages, PLA has some limitations: 1. Mechanical Properties: PLA is relatively brittle and may not provide sufficient mechanical support for certain applications. 2. Degradation Rate: The degradation rate of PLA can sometimes be inconsistent, which may affect the timing of tissue regeneration. 3. Hydrophobicity: PLA is hydrophobic, which can limit cell adhesion and proliferation. Surface modifications are often required to improve its hydrophilicity.
