The secretion of pancreatic amylase is tightly regulated by hormonal and neural mechanisms. The hormone cholecystokinin (CCK) is released by the small intestine in response to the presence of fats and proteins in the chyme. CCK stimulates the acinar cells to secrete digestive enzymes, including pancreatic amylase. Additionally, the vagus nerve provides parasympathetic stimulation that enhances enzyme secretion.
