How is Muscle Spasticity Diagnosed Histologically?
Diagnosis typically involves a combination of clinical assessment and histological examination. Muscle biopsies can be stained using various techniques to identify characteristic changes:
Hematoxylin and Eosin (H&E) Staining: This common staining method helps visualize general muscle architecture and any pathological alterations in muscle fibers. Masson's Trichrome Staining: This staining technique is used to detect fibrosis by highlighting collagen fibers in blue. Immunohistochemistry: Specific antibodies can be used to detect changes in proteins associated with the neuromuscular junction and muscle fibers.
