Several techniques and technologies contribute to the miniaturization of samples in histology:
1. Microtomy: Advances in microtomy have enabled the production of extremely thin sections of tissue, often in the range of 1-2 micrometers. These thin sections allow for detailed examination under a microscope. 2. Laser Capture Microdissection (LCM): LCM allows for the precise isolation of specific cells or regions from a tissue section, enabling targeted analysis of small, defined areas. 3. Microfluidics: Microfluidic devices can process tiny volumes of biological samples, facilitating the study of cellular interactions and dynamics in a controlled environment. 4. Nano-technology: The use of nanotechnology in histology includes the development of nanoscale probes and markers that can label specific cellular components, allowing for high-resolution imaging and analysis.
