How Do Metabolic Disorders Affect Histological Structure?

Metabolic disorders can have profound effects on the histological structure of tissues. For instance, diabetes mellitus can lead to changes in the kidney's glomeruli, resulting in diabetic nephropathy. Inherited metabolic disorders like Gaucher's disease can cause the accumulation of glycolipids in cells, leading to tissue damage and organ dysfunction. Histological examination of tissues affected by metabolic disorders often reveals specific patterns of cellular and extracellular changes.