What Techniques are Used to Study Presenilin in Histology?
Several histological techniques are employed to study presenilin and its effects on cellular and tissue structure. Immunohistochemistry (IHC) is widely used to detect presenilin expression in tissue sections using specific antibodies. Western blotting and immunofluorescence are also common methods for analyzing presenilin levels and localization. Advanced imaging techniques such as confocal microscopy and electron microscopy provide detailed insights into the ultrastructural changes associated with presenilin mutations. These techniques help elucidate the pathological processes at the cellular level, contributing to a better understanding of the mechanisms underlying Alzheimer's Disease.
