Lipolysis is tightly regulated by hormonal and neural signals. Key hormones include:
- Insulin: Inhibits lipolysis by promoting the storage of fats. - Glucagon: Stimulates lipolysis by activating HSL. - Adrenaline: Also known as epinephrine, it activates both HSL and ATGL through the β-adrenergic receptors.
Neural regulation involves the sympathetic nervous system, which can stimulate lipolysis via norepinephrine.