How is Invasiveness Identified in Histological Samples?
Invasiveness is identified by examining tissue samples under a microscope. Pathologists look for key features such as irregular cell shapes, increased nuclear size, abnormal mitotic figures, and the presence of cells breaching the basement membrane. Special stains and immunohistochemistry can highlight specific proteins associated with invasive behavior, such as matrix metalloproteinases (MMPs) and E-cadherin.
