How is Ineffective Hematopoiesis Identified Histologically?
Histologically, the bone marrow of patients with ineffective hematopoiesis often shows increased cellularity (hypercellularity) due to the marrow's attempt to compensate for peripheral deficiencies. A closer examination may reveal dysplastic changes in the hematopoietic cells, such as abnormal nuclear shapes, irregular cell sizes, and defective maturation stages. For instance, in megaloblastic anemia, one can observe the presence of large, abnormally developed erythroblasts called megaloblasts.
