hepatocyte necrosis

How is Hepatocyte Necrosis Identified Histologically?

Histological identification of hepatocyte necrosis involves examining liver tissue under a microscope. Key features include:
- Cell swelling: Hepatocytes appear enlarged due to fluid accumulation.
- Cytoplasmic changes: Increased eosinophilia, presence of Mallory bodies.
- Nuclear changes: Pyknosis (nuclear shrinkage), karyorrhexis (nuclear fragmentation), and karyolysis (nuclear dissolution).
- Loss of cell boundaries: Cells lose their membrane integrity and lyse.
- Inflammation: Presence of inflammatory cells, particularly neutrophils and macrophages.

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