Liver biopsies are often performed to assess the extent of hepatocyte damage. Histological staining techniques such as Hematoxylin and Eosin (H&E) staining, Masson's Trichrome staining, and Periodic Acid-Schiff (PAS) staining can help identify various features of hepatocyte injury. Immunohistochemistry may also be used to detect specific proteins that indicate liver damage.