How is hepatocellular carcinoma (HCC) identified histologically?

HCC, the most common primary liver cancer, arises from hepatocytes. Histologically, it shows varying degrees of differentiation. Poorly differentiated HCC may appear as highly atypical cells with large, hyperchromatic nuclei and frequent mitotic figures. Well-differentiated HCC can resemble normal hepatocytes but with architectural abnormalities such as trabecular or pseudoglandular patterns.