GAD65 has been implicated in several neurological and autoimmune diseases. In Type 1 Diabetes Mellitus, autoantibodies targeting GAD65 are commonly present, indicating an autoimmune response against pancreatic beta cells. In the context of neurological disorders, GAD65 dysfunction is associated with conditions such as epilepsy, where an imbalance in GABAergic signaling can lead to increased neuronal excitability. Additionally, alterations in GAD65 expression or function have been linked to psychiatric conditions like schizophrenia and bipolar disorder.
