In histology, fibrosis scoring is done by examining stained tissue sections under a microscope. Pathologists typically use special stains such as Masson's trichrome, Sirius red, or hematoxylin and eosin (H&E) to visualize collagen fibers and other extracellular matrix components. The extent of fibrosis is then graded based on established scoring systems, such as the METAVIR, Ishak, or Knodell scores.
