Detection of EBV in tissues can be accomplished through multiple methods. Immunohistochemistry (IHC) can identify EBV-associated proteins like EBV nuclear antigen (EBNA) and latent membrane protein (LMP). In situ hybridization (ISH) techniques can detect EBV-encoded RNA (EBER) within the infected cells. Polymerase chain reaction (PCR) can also be used to amplify and detect EBV DNA.
