Identifying a cribriform pattern requires a skilled histologist. The pattern is typically identified using light microscopy after staining the tissue sample with hematoxylin and eosin (H&E). The cribriform pattern appears as clusters of cells with multiple small, round, and uniform spaces or holes, giving it a sieve-like appearance. Immunohistochemical staining may also be employed to further characterize the tissue and confirm the presence of specific markers.