What Histological Changes Occur in Disorders Affecting Working Memory?
Several neurological disorders impact working memory, including Alzheimer's disease, schizophrenia, and ADHD. Histological studies have shown that Alzheimer's disease involves the accumulation of amyloid plaques and neurofibrillary tangles, leading to synaptic loss. In schizophrenia, alterations in synaptic connectivity and neurotransmitter systems have been observed. ADHD is associated with changes in the prefrontal cortex and catecholamine neurotransmitter systems.
