Cancer: CD38 is overexpressed in certain cancers like multiple myeloma and chronic lymphocytic leukemia (CLL). It serves as a therapeutic target for monoclonal antibodies such as daratumumab. Autoimmune Diseases: Abnormal CD38 expression is observed in autoimmune diseases like systemic lupus erythematosus (SLE) and rheumatoid arthritis. Metabolic Disorders: CD38 is involved in the regulation of insulin secretion and glucose metabolism, linking it to metabolic conditions like diabetes.
