Caldesmon activity is regulated through several mechanisms: 1. Phosphorylation: Protein kinases can phosphorylate caldesmon, altering its interaction with actin and myosin. 2. Calcium/Calmodulin Binding: Caldesmon binds to calmodulin in a calcium-dependent manner, causing conformational changes that modulate its function. 3. Proteolytic Cleavage: Specific proteases can cleave caldesmon, affecting its regulatory capacity.
