How is African Trypanosomiasis Diagnosed Histologically?
The diagnosis of African Trypanosomiasis can be confirmed through various histological techniques:
Microscopy: Direct observation of trypanosomes in blood, lymph node aspirates, or CSF using Giemsa or Wright stains. Immunohistochemistry: This method uses specific antibodies to detect trypanosomal antigens in tissue sections, enhancing the sensitivity and specificity of the diagnosis. Polymerase Chain Reaction (PCR): Although not purely histological, PCR can be used on tissue samples to detect trypanosomal DNA, providing a highly sensitive diagnostic tool.
