How Does Tissue Shrinkage Affect Histological Analysis?
Tissue shrinkage can impact the histological analysis by altering the morphology of cells and tissues. This can lead to:
1. Distortion of Structures: Shrinkage can cause distortion of cellular and tissue structures, making it difficult to interpret the normal architecture. 2. Misinterpretation: Changes in the size and shape of cells can lead to misinterpretation of pathological conditions. 3. Measurement Errors: Quantitative studies involving measurements of tissue and cellular components may be affected by shrinkage.
