How Does the PSD Complex Contribute to Synaptic Plasticity?
Synaptic plasticity refers to the ability of synapses to strengthen or weaken over time in response to activity levels. The PSD complex contributes to synaptic plasticity through the regulation of receptor trafficking and modifications in the composition of its protein constituents. For example, during long-term potentiation (LTP), an increase in synaptic strength is accompanied by the insertion of AMPA receptors into the postsynaptic membrane, a process mediated by PSD proteins. Conversely, during long-term depression (LTD), the removal of these receptors leads to a decrease in synaptic strength.
