The huntingtin protein interacts with various cellular structures, such as microtubules and vesicles, to facilitate intracellular transport. It also plays a role in the cytoskeleton stability and endocytosis. Histologically, cells expressing normal huntingtin exhibit well-organized organelles and efficient intracellular trafficking. In the nervous system, huntingtin is critical for axonal transport and synaptic vesicle recycling, which are essential for neuron function and health.
