How Does the Extracellular Matrix Contribute to Microenvironmental Heterogeneity?
The extracellular matrix (ECM) is a dynamic structure composed of proteins, glycoproteins, and proteoglycans. It provides structural support and regulates cell behavior through biochemical and mechanical signals. Variations in ECM composition and stiffness contribute to microenvironmental heterogeneity, influencing processes like cell migration, differentiation, and proliferation.