How Does TBI Affect the Blood-Brain Barrier (BBB)?
TBI often leads to disruption of the blood-brain barrier (BBB), which can be visualized histologically. Techniques such as immunohistochemistry for tight junction proteins (e.g., occludin, claudin-5) and electron microscopy can reveal breaches in the BBB. Leakage of serum proteins like albumin into the brain parenchyma is another indicator of BBB disruption.
