PYY exerts its effects through binding to specific receptors known as neuropeptide Y receptors (NPY receptors). There are multiple subtypes of these receptors, including Y1, Y2, Y4, and Y5. Among these, the Y2 receptor is particularly important for mediating the appetite-suppressing effects of PYY. These receptors are found in various tissues, including the hypothalamus, gastrointestinal tract, and pancreas.
