How does Primary Carnitine Deficiency Affect Muscle Tissues?
In muscle tissues, the lack of carnitine impairs the transport of long-chain fatty acids into the mitochondria. This results in the accumulation of lipids in the cytoplasm, which can be visualized using specific stains. Over time, this lipid accumulation can lead to muscle weakness and myopathy. Histological examination of affected muscles often reveals increased numbers of lipid droplets, disrupted muscle fibers, and sometimes fibrosis.
