Myc rearrangements typically occur through chromosomal translocations, where a segment of one chromosome breaks off and attaches to another chromosome. For instance, in Burkitt lymphoma, the MYC gene on chromosome 8 is translocated to chromosome 14, placing it near the immunoglobulin heavy chain (IGH) locus. This translocation leads to the deregulated expression of MYC, driving oncogenesis.
