Histology, the study of tissues at the microscopic level, can greatly benefit from multi-omics data. Traditional histological techniques involve staining and microscopic examination of tissue sections, which, while informative, provide limited molecular insights. By incorporating multi-omics approaches, researchers can overlay histological findings with molecular data, offering a more comprehensive view of tissue architecture and function. This integration can, for example, elucidate the molecular underpinnings of tissue heterogeneity in diseases like cancer.