MDMX primarily functions by binding to p53 and inhibiting its transcriptional activity. Unlike MDM2, which promotes the degradation of p53 through ubiquitination, MDMX does not directly induce p53 degradation. Instead, it modulates p53's activity, which can lead to the suppression of p53-mediated apoptosis and tumor suppression functions. This makes MDMX a crucial player in maintaining the balance between cell survival and cell death.
