How Does HPV DNA Contribute to Cancer Development?
HPV DNA contributes to cancer development by integrating into the host cell's genome, disrupting normal cell regulatory mechanisms. High-risk HPV types, such as HPV-16 and HPV-18, produce proteins like E6 and E7 that interfere with tumor suppressor proteins [p53](https://) and [RB](https://), leading to uncontrolled cell proliferation and eventually, cancer. Histological examination of tissues can reveal these changes and help in diagnosing HPV-related cancers.
