diastolic dysfunction

How Does Histology Help in Diagnosing Diastolic Dysfunction?

Histological examination provides detailed insights into the structural changes in the myocardium. Techniques such as histopathology and immunohistochemistry are used to identify and quantify the extent of fibrosis, hypertrophy, and inflammation. For instance:
Masson's trichrome stain can highlight fibrotic tissue by staining collagen fibers blue.
Hematoxylin and eosin (H&E) stain can be used to observe cardiomyocyte hypertrophy and general tissue architecture.
Immunohistochemical markers such as alpha-smooth muscle actin (α-SMA) can identify myofibroblasts involved in fibrosis.

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