Histological examination involves the analysis of tissue samples under a microscope. Key diagnostic techniques include:
Bone marrow biopsy: This involves extracting a small sample of bone marrow tissue, which is then stained and examined for abnormal cells. Immunohistochemistry (IHC): This technique uses antibodies to detect specific antigens in cells, helping to identify the type of malignancy. Flow cytometry: This analyzes the physical and chemical characteristics of cells or particles, aiding in the identification and classification of hematologic malignancies.